lec6-Coiled Coils

lec6-Coiled Coils - Coiled Coils 7.88J Protein Folding...

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Coiled Coils± 7.88J Protein Folding Prof. David Gossard September 24, 2003
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PDB Acknowledgements The Protein Data Bank (PDB - http://www.pdb.org/ ) is the single worldwide repository for the processing and distribution of 3-D biological macromolecular structure data. Berman, H. M., J. Westbrook, Z. Feng, G. Gilliland, T. N. Bhat, H.Weissig, I. N.Shindyalov, and P. E.Bourne. “The Protein Data Bank.” Nucleic Acids Research 28 (2000): 235-242. (PDB Advisory Notice on using materials available in the archive: http://www.rcsb.org/pdb/advisory.html ) PDB molecules and citations used in the “Coiled Coils” Lecture Notes for 7.88J - Protein Folding PDB ID: 2ZTA JRNL reference: O'Shea, E. K., J. K. Klemm, P. S. Kim., and T. Alber. “X-ray structure of the GCN4 leucine zipper, a two- stranded, parallel coiled coil.” Science 254 (1991): 539. Pages: 3 (“Outline”), 14-15 (“GCN4 Leucine Zipper”)
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Outline± • Review Key Features of Coiled Coils± • Examine a Particular Example – GCN4 Leucine Zipper (2ZTA)
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C Coiled Coils± Left-handed spiral of right-handed helices± • May be parallel N N C C or anti-parallel N C N
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2-Stranded Coiled Coils± •G C N 4 •² Tropomyosin •² Intermediate filament protein •L a m i n •² M-protein •² Paramyosin •M y o s i
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z(t) = P ( Z o t /2 S ) Crick’s Models± • Geometry of Helix (Coil) x y z t r o P Z o Z > 0 right-handed o R(t) x(t) = r o cos( Z o t)± y(t) = r o sin( Z o t)±
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This note was uploaded on 02/21/2008 for the course BIOL 7.88 taught by Professor Gossard during the Fall '03 term at MIT.

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lec6-Coiled Coils - Coiled Coils 7.88J Protein Folding...

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