Reactions o proximity and orientation effects 1 ch369

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Unformatted text preview: example of chymotrypsin o Know the catalytic triad and the role of each of the three residues o Know the reaction mechanism and order of steps 6- 3: • Know the two models for substrate binding o Lock and key model o Induced fit model o Understand model of chymotrypsin and role of oxyanion hole §༊ Know how the oxyanion intermediate is stabilized by H- bonds §༊ Further stabilized by low- barrier H- bond between His and Asp • Understand the beneficial effects of enzymes on chemical reactions o Proximity and orientation eff...
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