4060 of human genes have alterna4ve splicing forms

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Unformatted text preview: P CTD (m7G) Alterna4ve Splicing •Different combina4ons of exons could be spliced together to produce different mRNA isoforms of a gene. • Alterna4ve splicing is now considered one of the main mechanisms responsible for increasing the diversity and complexity of the human genome. • 40–60% of human genes have alterna4ve splicing forms. • 10–30% of alterna4vely spliced human genes possess 4ssue ­ specific splice form.. •at least 15% of muta4ons that cause gene4c diseases affect pre ­mRNA splicing Discovery of Ribozyme •  RNA can self ­splice Thomas Cech Tetrahymena [Adapted from Kruger et al., 1982, Cell 31:147.] Group I Group II RNA edi4ng The Nuclear Pore Nuclear transport •  Metal ions, small metabolites, and molecules less...
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This document was uploaded on 03/09/2014 for the course BIOLOGY biocore at NYU.

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