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Transla4on transla4on ini4a4on transla4on elonga4on

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Unformatted text preview: than ∼40 kDa in mass or ∼5 nm in diameter can pass rela4vely freely. •  Larger macromolecules overcome this permeability barrier by interac4ng either directly with the NPC themselves or through soluble transport factors. •  NPC is capable of transpor4ng cargo up to 39 nm in diameter •  Macromolecules larger than 39 nm can s4ll be translocated across the NPC Forma4on of heterogeneous ribonucleoprotein par4cles (hnRNPs) and export of mRNPs from the nucleus. Transla4on Transla4on Ini4a4on Transla4on elonga4on Transla4on termina4on •  Polyribosome •  Rapid recycling of ribosomal subunits Cytoplasmic Polyadenyla4on and polyA length regula4on RNA degrada4on Fig.8 ­29 Global regula4on of protein synthesis Sequence ­specific RNA ­binding proteins and transla4on control • 5’UTR example: Ferri4n. • 3'UTR example: Tranferrin ­receptor. Sequence ­spec...
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