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Binding of hormone causes a conformaon change that

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Unformatted text preview: t property do steroids have with respect to the cell membrane? 9 nuclear receptor – cytoplasmic [email protected] Type I., androgen, estrogen, progesterone, [email protected] 1. Hormones very ohen are lipid soluble and cross the plasma membrane passively but not the nuclear envelope. 2. Therefore, one large class of nuclear receptors perceive the hormone signal in the cytoplasm Chaperone bound, cannot enter nucleus Ligand bound form enters nucleus 3. Binding of hormone causes a [email protected] change that allows nuclear receptor to pass nuclear membrane and act as a [email protected] factor. Thus, a nuclear receptor has a ligand binding domain, a DNA binding domain, and an [email protected]@on domain 10 TGF- β – puzzle pieces 1. TGF- β is ligand 2. Receptor is a serine threonine kinase 3. Receptors dimerize but [email protected] is between two unlike Ser/Thr kinases ([email protected]) 4. [email protected] sets up a [email protected] cascade, relaying the phosphorylated state to Smad proteins “monogomous” – one set of targets - - Smads many effects but one typical effect is to control growth Can be an autocrine, paracrine or endocrine signal, e.g., BMP7 5. Phosphorylated Smads can enter the nucleus and [email protected] [email protected] 11 Receptor Tyrosine Kinases 1.  RTKs typically [email protected] as dimers as well and can [email protected] as homo or heterodimers 2.  Different isoforms bind different ligands 3.  Important ligands in humans are Epidermal Growth Factors (EGFs) that bind Human Epidermal Growth Factor Receptors (HERs). Important Roles in Breast Cancer 12 G- Proteins 13 RAS- RAF – small G protein...
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