BiocoreIISignaling2014preclass

Could be an ion channel 15 g protein coupled receptors

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Unformatted text preview: mediated Cell division and cell mobility - - VERY IMPORTANT IN CANCER RESEARCH 1. One pathway to RAS- RAF signaling is through the Epidermal Growth Factor (EGF) ligand and its receptor Epidermal Growth Factor Receptor (EGFR) 2. Signal [email protected] affects the state of RAS – a monomeric G protein 3. EGF signaling leads to [email protected]@on of RAS, which signals to RAF, eventually leading to [email protected] [email protected]@on 4. Signaling from the same pathway eventually leads to exchange of GTP to GDP [email protected]@ng RAS 14 “Large” trimeric G protein signaling via G Protein Coupled Receptors (GPCRs) 1.  Trimeric G proteins have three components: 1. G alpha, 2. G beta, 3. G gamma and the GDP/GTP 2.  The GPCR binds its ligand, which causes a change in its shape. 3.  The G- protein [email protected] dissociates. Typically, G alpha- GTP is the signal that [email protected] another effector on the cell membrane. Could be an ion channel. 15 G- Protein Coupled Receptors (GPCRs) Ligand Binding Domain 16 GPCR Rhodopsin No real ligand per se – what triggers [email protected] change? In this case, the GPCR acts as a guanine [email protected] exchange factor (GEF) 17 •  Paracrine (endocrine) signaling Local [email protected] in development You cells over there start making a limb 18 [email protected] Mediated Signals 19 Wnt Signaling •  •  •  •  •  •  Cancer Stem cells Morphogenesis Neurogenesis Growth Axon guidance 20 Proteasomal [email protected] Where does specificity come from? proteasome 21 Anaphase [email protected] Complex APC – E3 Ligase Degraded during APC signaling [email protected] During APC signaling Securin Separase Cohesin The APC- E3 ligase se...
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This document was uploaded on 03/09/2014 for the course BIOLOGY biocore at NYU.

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