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2013 nature s aureus uses luked to injure ccr5

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Unformatted text preview: ead Cells (Cell Titer) 100 LukED Concentration (µ g/ml) Alonzo F et al. 2013 Nature Gain- of- Func-on Experiment 100 Jurkat Jurkat+R5 % Dead Cells (Cell Titer) 80 60 40 20 H9 H9+R5 80 60 40 20 Toxin Concentration (µ g/ml) 40 20 10 5 5 2. 25 1. 63 0. 31 0. 40 20 10 5 5 2. 25 1. 0. 63 0 31 0 0. % Dead Cells (Cell Titer) 100 Toxin Concentration (µ g/ml) Alonzo F et al. 2013 Nature LukED Targe-ng of CCR5+ Cells and Clinically Used CCR5 Antagonists Alonzo F et al. 2013 Nature LukED Kills Primary Human Leukocytes Decorated With CCR5 Alonzo F et al. 2013 Nature LukED Binding to the Plasma Membrane of Host Cells Alonzo F et al. 2013 Nature Binding of LukED to CCR5 CCR5 LukD LukE Dr. David G. Myszka Biosensor Tools LLC Salt Lake City, Utah LukE MVC: - + CCR5 LukE Alonzo F et al. 2013 Nature S. aureus Uses LukED To Injure CCR5+ Leukocytes in vivo CCR5+/+ or CCR5- /- mice were infected IP with S. aureus...
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