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2014 trends in microbiology human mouse human mouse

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Unformatted text preview: HlgCB) leukocidin ED (LukED) leukocidin AB (LukAB) % Death hPMNs (Cell Titer) S. aureus Bi- component β- Barrel Pore- Forming Toxins Bi- component Leukotoxins: Similar But Not Redundant Toxins LukED PVL LukAB HlgACB Cytotoxin Cell Type Specificity PMN Macrophage PMN PMN Monocyte Macrophage PMN RBC DC Monocyte T- cell DC Macrophage Monocyte Monocyte Macrophage RBC Human Species Specificity Mouse Human Mouse = Modified from: DuMont and Torres. 2014, Trends in Microbiology Human Mouse Human = ≠ Mouse LukED as A Model to Study the Contribu-on of Leukotoxins to Staph pathogenesis Development of acute infec6on monitored over 6me 100 Percent survival Mice infected by IV injec6on (retro- orbitally) with S. aureus strains 80 WT Δ lukED Δ lukED::lukED 60 40 20 0 0 50 100 150 200 250 300 Time (Hours) Alonzo F et al. 2012 Molecular Microbiology LukED and Staph Replica-on Within Infected Tissues KIDNEY 96 Hours *** *** D D kE :lu D: kE WT kE Δlu Δlu Δlu kE D: :lu Δlu kE kE D D 9 8 7 6 5 4 3 2 WT Log10 (CFU/Organ) 16 Hours Alonzo F et al. 2012 Molecular Microbiology Iden-fica-on of LukED Receptors LukED Selec-vely Kills The Human T Lymphocyte Line Hut- R5 80 60 Hut-R5 PM1 H9 Jurkat Hut-R5...
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