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Elr cxc ligands cxcr1 cxcl6 cxcl8 cxcr2 cxcl1 cxcl2

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Unformatted text preview: 24 hr post infec6on leukocytes were collected from the peritoneum, stained and analyzed by flow cytometry CCR5 -/WT 10 8 CFU/ml (kidney) 100 90 80 70 60 50 40 30 20 CCR5+/+ + Sa ΔlukED 10 7 10 6 10 5 0 50 10 150 200 250 300 350 400 0 Percent survival Contribu-on of CCR5 Targe-ng to Bloodstream Infec-on Time (Hours) + /+ -/- 5 R5 CR CC C Alonzo F et al. 2013 Nature But wait, how LukED kills PMNs? LukED Also Kills Leukocytes in a CCR5- Independent Manner PMNs Lymphocytes (CD3) Monocytes (CD14) Reyes- Robles T et al. 2013 Cell Host & Microbe Pore Forma-on (EtBr, RFUx104) Screening GPCRs For Addi-onal LukED Cellular Targets 60 40 20 0 Reyes- Robles T et al. 2013 Cell Host & Microbe CXCR1 and CXCR2 (CD181 & CD182) hPMNs CXCR1 ü༏  Also known as the IL- 8RA and IL- 8RB G- protein coupled receptors ü༏  ~ 77% amino acid sequence iden6ty ü༏  Found on PMNs, m...
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This document was uploaded on 03/09/2014 for the course BIOLOGY biocore at NYU.

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