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Vicriviroc taq 779 liu sq et al model of hccr5 pdb

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Unformatted text preview: J u rk a t H9 40 20 LukED Concentration (µg/ml) 40 20 10 5 0 0. 31 0. 63 1. 25 2. 5 % Dead Cells (Cell Titer) 100 0 1 10 10 CCR5 10 2 10 3 4 10 Alonzo F et al. 2013 Nature C- C Chemokine Receptor 5 (CD195) ü༏  Seven transmembrane G- protein coupled receptor (GPCR) involved in leukocyte migra6on ü༏  β chemokine receptor family (CCL3, CCL4, CCL5, and CCL8) ü༏  Macrophages, DC, Effector/Central Memory T Cells, Microglia ü༏  Co- receptor required for HIV entry into target cells (1996; it was all about CCR5) (2 Nature, 1 Science, 2 Cell) ü༏  Individuals with the Δ32 CCR5 allele are resistant to HIV ü༏  Several receptor antagonists have been developed (Maraviroc, Vicriviroc, Taq- 779) Liu SQ et al. Model of hCCR5 (PDB 1ND8 ). Loss- of- Func-on Experiment Ctrl shRNA CCR5 shRNA 80 60 40 20 20 10 5 2. 5 1. 25 0. 63 0. 31 0 0. 15 % D...
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This document was uploaded on 03/09/2014 for the course BIOLOGY biocore at NYU.

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