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2-Evol Perspectives Figs BW

Bach j f 2002 new england j med 347911 920 hygeine

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Unformatted text preview: disease, Multiple sclerosis, type 1 diabetes, asthma). Bach, J-F (2002) New England J Med 347:911-920 Hygeine Hypothesis: Evidence for Mechanisms Science 336: 489-493 (2012) experiment: have mice with normal microbiota and mice grew in sterilized environment. If you expose these 2 types of mice to pathogens that invoke inflammatory bowel disease and asthma, the mice grew with normal microbiota rarely get sick. Those mice grew up germ free get sick a lot. www.taconic.com Inflammatory Bowel Disease Asthma potentially cause by Invariant Natural Killer T-Cells Normal Microbiota Germ Free* Rare Rare Low Common Common High *Effects reversed by infection in neonates but not adults. Role of Invariant Natural Killer T-Cells B-Lymphocytes (secrete antibodies) normally, the gene making the chemokine that stimulate production of iNKT cell is suppressed in mice with normal microbiota. Myeloid-Derived Suppressor Cells (inhibit immune cells) Natural Killer Cell (cytotoxic, non-specific) iNKT=invariant natural killer T cell. cytotoxic lymphocyte interact with all other lymphocyte overly abundant in germ-free mice Dendritic Cells (present antigens) CD8+ Cells (cytotoxic T-cells) CD4+ Cells (helper T-cells) Q: Why would bacteria do this? A: because symbiotic relationship between mice (human) and bacteria. Note: 80% of immune system is in the digestive tract Figure from Cerundolo et al. (2009) Nature Rev. Immunol. 9:28-38...
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