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Unformatted text preview: disease, Multiple sclerosis, type 1 diabetes,
asthma). Bach, J-F (2002) New England J Med 347:911-920 Hygeine Hypothesis: Evidence for Mechanisms
Science 336: 489-493 (2012) experiment: have mice with normal microbiota and mice grew in sterilized
environment. If you expose these 2 types of mice to pathogens that invoke
inflammatory bowel disease and asthma, the mice grew with normal
microbiota rarely get sick. Those mice grew up germ free get sick a lot. www.taconic.com Inflammatory Bowel Disease
Invariant Natural Killer T-Cells Normal
High *Effects reversed by infection in neonates but not adults. Role of Invariant Natural Killer T-Cells
normally, the gene making the
chemokine that stimulate production
of iNKT cell is suppressed in mice
with normal microbiota. Myeloid-Derived
(inhibit immune cells) Natural Killer Cell
(cytotoxic, non-specific) iNKT=invariant natural killer T cell.
interact with all other lymphocyte
overly abundant in germ-free mice Dendritic Cells
(cytotoxic T-cells) CD4+ Cells
(helper T-cells) Q: Why would bacteria do this?
A: because symbiotic relationship between
mice (human) and bacteria.
Note: 80% of immune system is in the
digestive tract Figure from Cerundolo et al. (2009) Nature Rev. Immunol. 9:28-38...
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- Spring '09