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Cl- 105 mM + on the right are 4 symports (transport substance in the
1. sodium chloride symport
2. sodium potassium or sodium potassium 2 chloride
3. potassium driven chloride symport
4. large class of 2nd transport that are sodium dependent
(use energy stored in sodium electrochemical gradient to
power the movement, usually uptake of sugars, amino
note: the sodium-dependent glucose transporters is
called SGLUT Na+
Sugars, AAs, NTs SYMPORTS + sodium-dependent amino acid,
peptide work same way as sugar.
effective in oral rehydration
Transport Apical cell have low sodium inside, electroelectrical gradient for
sodium go inward. Na+-Glucose
Channel This is an epithelial cell.
Epithelial cell is polarize. black spots are tight junction. In the
kidney, glucose is filter, reabsorb. The whole thing is power
by pump (Na+-k+ ATPase).
In the apical membrane, the main way sodium can get
through the membrane is through that electrochemical
Potassium through apical membrane. This is a mechanism
of absorption of sodium
Diet Basolateral Tight
Transporter take transporters and put them together. this is epithelial cell (line lumen of kidney or intestine). epithelial cells are
always polarize: one side faces the lumen of hollow organ (apical surface, contain microvilli to increase surface area),
the rest of cell call basolateral. the black spot are tight junction (control movement of substance in between the cell)
b/c epithelium act as selective membrane between lumen and other side (capillaries-absorbing or secreting
substances that are crossing the epithelium from one direction or the other).
-this is about transepithelial gl...
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This document was uploaded on 03/09/2014 for the course EXSC 301 at USC.
- Spring '09