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Unformatted text preview: ly degradtion of CFTR)
pump out by the sodium potassium pump to maintain low
-affect pancreas (produce alkaline fluid neutralize acidic
sodium ion in the cell. **what's the whole point of the bottom
fluid in stomach), lung, colon.
transports: to bring chloride into the cell.***
-unfunctional CFTR in lung and pancreas: this means
-so chloride comes into the cell, its concentration build up and
the mucus don't have enough water content. without a
in the apical membrane there's a CFTR (cystic fibrosis
functional CFTR, chloride and sodium and water cannot
[mutation for gene for this transporter caused the disease
be transported, mucus get too thick (proteins, lysozyme
cystic fibrosis] transmembrane conductance [inverse of
accumulate). in lung, thicken mucus cannot get rid of by
resistance, impede flow of current like movement of chloride]
cilia, so mucus accumulate and cause infection. in
regulator), which is a chloride channel.
pancrea, thicken mucus block the duct, cause
-see in membrane are transporters (sodium-potassium pump,
-CFTR in intestine (in colon) is normally responsible for
aquaporin in green)
salt-water transport to upper direction into the lumen,
-mucus protect, traps matter. if mucus is too thin, cause
affecting the water content of the stool (stool need to
diarrhea b/c have too much water.
have high enough water content so constipation won't
-sodium/potassium pump keep internal low sodium ion
occur, but water content can't be too high or diarrhea
-sodium chloride channel: bring chloride into the cell, build its
occur). there are a number of bacteria that cause
gastroretis, that can spread through diarrhea. this
-CFTR: chloride channel, cystic...
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- Spring '09