Unformatted text preview: fibrosis transmembrane
disease spread rapidly through contaminated water.
conductance (inverse of resistance, impede flow of current)
some toxin can strongly activate the CFTR (bacteria
regulator. CFTR is phosphorylated by cAMP-dependent
might also have receptor that bind to CFTR and use it to
kinase (protein kinase A), this opens the channel and then
enter the cell. so CFTR induce diarrhea to spread
moves chloride out (movement of chloride across
bacteria and route of infection for bacteria to enter),
transmembrane-remember high cl concentration inside cell).
induce diarrhea, cause excessive secretion of salt and
THIS BUILD UP ELECTRONEGATIVITY IN THE MUCUS,
water and sodium (excess fluid in the intestine). cause
which drive diffusion of sodium ions through the tight junction
cholera (very serious disease, cause death, spread
through this paracellular (in between epithelial cell) membrane
rapidly. within hours cause hyponatremia-less than
out to maintain electroneutrality. movement of sodium and
appropriate amount of sodium in the blood, fatal within
chloride out create osmolarity channel for WATER FOLLOWS
hour). the treatment of cholera (antibiotics, oral
(through paracellular tight junction and aquaporin)-RESULT:
rehydration solution). vibrio cholerae
ACTIVE TRANSPORT OF SODIUM CHLORIDE AND H2O
-cystic fibrosis is common 1 to 2500 birth in caucasian.
into the fluid lining the apical surface
quality of life and life expectancy diminish.
here's another epithelial cell. the lumen is above so apical membrane is above the tight junction. basolateral membrane is below tight junction. if transport happen in the lung, the surface of epithelial cell in
lumen is cover with mucus and air. if colon, have mucus then liquid of...
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- Spring '09
- Sodium, Secondary Active Transport, Membrane transport protein, Na+/K+-ATPase