{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

3-Membrane Dynamics Figs BW Corrected

This cftr chloride channel cystic fibrosis

Info icon This preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: fibrosis transmembrane disease spread rapidly through contaminated water. conductance (inverse of resistance, impede flow of current) some toxin can strongly activate the CFTR (bacteria regulator. CFTR is phosphorylated by cAMP-dependent might also have receptor that bind to CFTR and use it to kinase (protein kinase A), this opens the channel and then enter the cell. so CFTR induce diarrhea to spread moves chloride out (movement of chloride across bacteria and route of infection for bacteria to enter), transmembrane-remember high cl concentration inside cell). induce diarrhea, cause excessive secretion of salt and THIS BUILD UP ELECTRONEGATIVITY IN THE MUCUS, water and sodium (excess fluid in the intestine). cause which drive diffusion of sodium ions through the tight junction cholera (very serious disease, cause death, spread through this paracellular (in between epithelial cell) membrane rapidly. within hours cause hyponatremia-less than out to maintain electroneutrality. movement of sodium and appropriate amount of sodium in the blood, fatal within chloride out create osmolarity channel for WATER FOLLOWS hour). the treatment of cholera (antibiotics, oral (through paracellular tight junction and aquaporin)-RESULT: rehydration solution). vibrio cholerae ACTIVE TRANSPORT OF SODIUM CHLORIDE AND H2O -cystic fibrosis is common 1 to 2500 birth in caucasian. into the fluid lining the apical surface quality of life and life expectancy diminish. here's another epithelial cell. the lumen is above so apical membrane is above the tight junction. basolateral membrane is below tight junction. if transport happen in the lung, the surface of epithelial cell in lumen is cover with mucus and air. if colon, have mucus then liquid of...
View Full Document

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern