3-Membrane Dynamics Figs BW Corrected

This create a net negativity inside the cell so this

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Unformatted text preview: his create a net negativity inside the cell, so this pump is electrogenic. the electronegenic property of this pump contribute to resting potential in some cells. Uniports Ca2+ ATPase H+ ATPase ATP ADP ICF Δ conformation Pi Δ conformation = Na+ Fig. 5-15 = K+ Secondary Active Transport 2K+ 3Na+ Ca2+ ATP Na+ H+ sodium calcium exchanger sodium proton exchanger (exchanger=antiport) chloride bicarbonate exchanger Cl- K+ Cl- HCO3- ANTIPORTS Na+ ClNa+ K+, 2Cl- 3Na+ ADP + Pi Na+ 15 mM K+ 150 mM Cl- 7 mM + this diagram show 7 2nd active transport. in 2nd active transport the energy of ions moving down its electrochemical gradient power the movement of another ion/molecule against its gradient. the numbers in the middle and bottom show the typical sodium, potassium and chloride concentraion in mammalian cell. typically, there are lower sodium and higher potassium inside the cell. most cases, this electrochemical gradient is establish by secondary active transport (mostly through sodium potassium ATPase). in most cases the ions that will power the secondary active transport is sodium ions moving into the cell (see upper left and right hand side). the 3 antiport in lower left which move ions across membrane in 2 opposite direction. the 4 transporters on the right are symport because they move ions across membrane in the same direction. -exception: 2 transporters are power differently. the one on the lower left is power by electrochemical gradient of chloride or bi carbonate. the one on right the potassium chloride symport is driven by outward driven electrochemical gradient for potassium -for most transporters, transport is power by sodium gradient, established by sodium potassium ATPase which play central role in powering cell. Na+ 140 mM K+ 4 m...
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This document was uploaded on 03/09/2014 for the course EXSC 301 at USC.

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