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Unformatted text preview: Enhances Ca2+
channels in plasma
membrane Ca2+ channel Ca2+ / CaM kinase Cellular
response modified from Fig. 6-12 Arachidonic
Acid System Arachidonic Acid this acid system can serve on this pathway. or there's a second way to generate arachidonic acid system. G-protein are activated by binding of ligand and activate a different membrane-enzyme phospha A 2.
A2 break down insitol to arachidonic acid. this arachidonic acid, same as previous slide (from DAG), but synthesize by another pathway. Arachidonic acid itself have second messenger activity. but most of this
activity act through its conversion to a very large family of 20-carbon signal molecules. so arachido is a substrate for synthesis of 20-c signaling molecule called collectively eicosanoids. there are 3 major
classes or eicosanoids. the leukotrienes are synthesized from arachi by enzyme lipoxygenase. this leukotrienes are signal molecules best studied in leukocytes (white blood cells where they are known to play
a major role in asthma and severe allergic reaction). the prostaglandins and thromboxanes are the second and third derivatives...
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- Spring '09