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-these are small molecules, uncharged, not polar, so can diffuse through membrane and dissolve in aqueous solution so they are permeable through everything. so they are very mobile
and diffuse rapidly from their place of generation. so they cannot be store in advance, cannot be store in vesicles since they'll diffuse out. which means they have to be synthesize on
demand. and have very short half-life. so these are mostly **paracrine hormones**. they don't last very long in the blood and travel long distance. they act locally on adjacent cells. there
are many overlapping function of these 3. they all inhibit inflammation, stimulate vasodilation (relaxation of smooth muscle, particularly in arteriole to increase blood flow into capillary
beds), microvascularization (growth of small blood vessels (capillary) into tissue, so help form new capillary beds) Gaseous Signal Molecules: NO, CO and H2S - All inhibit inflammation, stimulate vasodilation, promote microvascularization lead to erection in the penus. inhibits phosphodiesterase that break down cGMP. the
signal initiated by NO in vasodilat...
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This document was uploaded on 03/09/2014 for the course EXSC 301 at USC.
- Spring '09