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Unformatted text preview: llular response (by binding to CaM, CaM
kinase phosphorylate and cause cellular response).
-IP3 CAN be converted to IP4 inside the cell. IP4 enhances calcium channels (increase the conductance/permeability-like of calcium channel in plasma membrne, allowing more calcium to enter the cell)-this
is one way cells can accumulate calcium so that calcium can be pump into the ER and be store as second messenger. DAG / IP3* System * Diacylglycerol / Inositol Trisphosphate -DAG is converted to arachidonic acid, soluble second messenger. arachidonic acid is itself a second messenger and a precursor for other messenger molecules. not all DAG are converted to ara acid, some
stay in membrane and they can activate another kinase, kinase C, a membrane-bound kinase. c will phosphorylate protein when it bind DAG to bring cellular response. Phospholipase C
IP4 increases conductance
of calcium ion. Route where
cells can accumul ate
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This document was uploaded on 03/09/2014 for the course EXSC 301 at USC.
- Spring '09