This preview shows page 1. Sign up to view the full content.
Unformatted text preview: hand side of no ligand present and the gate is closed (in the absence of ligand). when the ligand is present, the gate move the way to open the pore,
causing an influx of sodium into the cell, a change in membrane potential, change some voltage or calcium sensitive protein , creating a cellular response Ligand-Gated Ion Channels
Leakage K+ Channel Ligand-gated
Na+ K+ Ligand ECF
(0 mV) Vm
(-70 mV) K+
Open K+ channels
generate resting Vm Ligand binding → Na+ influx →
ΔVm → Δ voltage or Ca2+-sensitive
protein → cellular response know how binding of pair of signaling molecule to extracellular portion of trk receptor causes trk to dimerize. when trk dimerize, they
become active. at intracellular side of activated dimer, the enzymes have kinase activity, autophosphorylate itself and trigger binding
of number of accessory proteins (relay proteins), each of which of secondary effect including generation of other secondary
messenger. the final result is activation of mu...
View Full Document
This document was uploaded on 03/09/2014 for the course EXSC 301 at USC.
- Spring '09