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4-Cell Communication Figs BW

For a sodium channel on the right the left hand side

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Unformatted text preview: hand side of no ligand present and the gate is closed (in the absence of ligand). when the ligand is present, the gate move the way to open the pore, causing an influx of sodium into the cell, a change in membrane potential, change some voltage or calcium sensitive protein , creating a cellular response Ligand-Gated Ion Channels Leakage K+ Channel Ligand-gated Na+ Channel Na+ K+ Ligand ECF (0 mV) Vm ICF (-70 mV) K+ Open K+ channels generate resting Vm Ligand binding → Na+ influx → ΔVm → Δ voltage or Ca2+-sensitive protein → cellular response know how binding of pair of signaling molecule to extracellular portion of trk receptor causes trk to dimerize. when trk dimerize, they become active. at intracellular side of activated dimer, the enzymes have kinase activity, autophosphorylate itself and trigger binding of number of accessory proteins (relay proteins), each of which of secondary effect including generation of other secondary messenger. the final result is activation of mu...
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