4-Cell Communication Figs BW

The final result is activation of multiple signal

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Unformatted text preview: ltiple signal transduction pathways. Receptor-Enzymes Receptor Tyrosine Kinase (Trk) OUT P Dimer (active) P P P Monomers (inactive) P P P IN P Autophosphorylation Binding of Accessory Proteins Activation of Multiple Signal Transduction Pathways G-Protein Coupled Receptors (cAMP System – 1) Receptor Ligand Adenylyl cyclase GS Protein βγα G protein use as a trimer GTP GDP GTP GDP Inactivation ATP Activated subunits βγ α GTP GDP ***important*** first 2 not that important how it work: outside is above membrane. Unstimulated state (no ligand bound)-g protein exist as a trimer bind to GDP. when ligand bind receptor, that cause G protein to bind to cytoplasmic side of receptor and that cause GDP to come off and be replace by GTP. THE Binding of GTP to trimer cause it to break apart to 2 piece (alpha and beta-gamma) and lose its affinity to receptor, so the 2 pieces (beta-gamma) come off and diffuse leading to membrane. as long as ligand is bound, this receptor will catalyze the splitting and activation of many G proteins. these G proteins activated beta-gamma system (al...
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