Unformatted text preview: of the arachidonic acid. they are synthesize by enzyme cycloxygenase. there are
2 types cox 1 and 2. these prostaglandins and thromboxanes are involve in many pathways invovle in inflmmation, pain,response to injury, affect smooth musclke. drugs to inhibit cox to cause supression of
inflammation and relief of pain. drug called anti-inflammatery (Anceps, aspirin) inhibit both COX enzymes. problem with drug is that inhibition of Cox1 is associate with stomach bleeding. so researcher try to
focus on cox 2: cylabex. (Phospholipase A2) Phosphatidyl
inositol DAG G Protein (LOX) Modified
from Fig. 6-16 Eicosanoids
(20-C) synthase from
Epoxygenase inhibition of COX1 lead to
stomach bleeding integrin receptor (membrane-bound receptor) have 2 dissimilar subunit, alpha and beta. when
this receptor bind to its ligand (molecules of extracellular matrix or antibodies or blood-clotting
proteins). when the receptor binds its ligands, then the receptor clustered and become active...
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This document was uploaded on 03/09/2014 for the course EXSC 301 at USC.
- Spring '09