4-Cell Communication Figs BW

The prostaglandins and thromboxanes are the second

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Unformatted text preview: of the arachidonic acid. they are synthesize by enzyme cycloxygenase. there are 2 types cox 1 and 2. these prostaglandins and thromboxanes are involve in many pathways invovle in inflmmation, pain,response to injury, affect smooth musclke. drugs to inhibit cox to cause supression of inflammation and relief of pain. drug called anti-inflammatery (Anceps, aspirin) inhibit both COX enzymes. problem with drug is that inhibition of Cox1 is associate with stomach bleeding. so researcher try to focus on cox 2: cylabex. (Phospholipase A2) Phosphatidyl inositol DAG G Protein (LOX) Modified from Fig. 6-16 Eicosanoids (20-C) synthase from arachidonic acid through enzyme Epoxygenase inhibition of COX1 lead to stomach bleeding integrin receptor (membrane-bound receptor) have 2 dissimilar subunit, alpha and beta. when this receptor bind to its ligand (molecules of extracellular matrix or antibodies or blood-clotting proteins). when the receptor binds its ligands, then the receptor clustered and become active...
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