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4-Cell Communication Figs BW

These g proteins activated beta gamma system also

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Unformatted text preview: so alpha) activate secondary messenger. bind and activate to adenylyl cyclase (at cytoplasmic side), activate conversion ATP TO cAMP. -hydrolysis of GTP TO GDP inactivate this process. cAMP G-Protein Coupled Receptors (cAMP System – 2) Adenylyl cyclase RS G S - + Gi Ri ATP AMP cAMP Phosphodiesterase + Protein Kinase A (cAMP-dependent Protein Kinase) Gs act on adenyl cyclase to increase cAMP. Gi inhibit adenyl cyclase to lower concentration cAMP in cytoplasm. cAMP activate protein kinase A, which go on to activate many many proteins. this signal transduction cascade is terminated by hydrolysis of cAMP to AMP through phosphodiestera se which is regulated by other membrane receptors. Regulated by other membrane receptors Phosphorylation of many target proteins (kinases, phosphatases, transmitter synthetic enzymes, channels, pumps, structural proteins, gene regulatory proteins. also G-protein couple system. g-protein have 7 transmembrane segments through receptor. signaling molecules bind. the G-protein is split as shown i...
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