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and the activity of the receptor on the intracellular side is complicated and it is associated with
intracellular proteins. differences in intracellular protein give diversity of signaling pathways. 2
proteins important (effector protein) are FAK AND Src. Fig. 6-5 Integrin Receptors these 2 kinases exert their effects by mediating the effects of
signal pathway by phosphorylating various proteins inside the
cells. when the receptor cluster like this, this integrin receptor also
associate indirectly with cytoskeleton. so the receptors bind to
actin filament when clustered and that's part of their activation.
-the function of these receptors are very diverse and important:
involve in blood clotting, healing of wounds, immune recognition,
cell movement, cell adhesion
-also important in cancer and spread of cancer cell. 3 FAK = focal adhesion kinase
Src = Src tyrosine kinase
Heterodimer * clustered ** http://www5.appliedbiosystems.com/tools/pathway/pathway.php?pathway=Integrin%20Pathway not ions but gase...
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This document was uploaded on 03/09/2014 for the course EXSC 301 at USC.
- Spring '09