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Unformatted text preview: h release. epsp get progressively diminish. have very
short time-course. mechanism involve is depletion of releasable transmitter stores (needs time
to replenish, refill the vesicle with neurotransmitter).
1-3 occur in all cells.
4. not all synapse show this: at CNS, LTP (asterisk have no meaning). you stimulate synapse,
have EPSP that look at Potentiation. release glutamate as transmitter acting through (NMDA
receptor). very very long lasting. stimulating rat at high frequency will leave permanent change
in rat's life. so this can have permanent effect on potentiation. LTP is a candidate for learning
and memory. ex: some experience like car crash cause long term memory and yet those
experience is brief. the effect is mostly post-synaptic mechanism (more glutamate receptor
NMDA type in post synaptic cell)
5. long-term depression: certain depression, depress effect last...
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- Spring '09