Unformatted text preview: ur) is on or at target organ, making postg short.
ganglion is not well-develop for parasympathetic. ganglion is
develop for sympathetic. Sympathetic =
Thoracolumbar 1 – cervical ganglia
2 – prevertebral ganglia
3 – adrenal medulla Parasympathetic
= Craniosacral Transmitters & Receptors (Traditional View)
the neural transmitter at all ganglionic synapse (whether para at top or sympathetic is
acetylcholine and only acetylcholine. acetylcholine act on nicotinic acetylcholine receptor on
postganglionic cell body, cause conductance increase for sodium and potassium, result in large
depolarization and fast EPSP (comes on rapidly and decay rapidly, strong excitation)> so it is
thought that this ganglionic synapse are just relay/passageway of info like neuralmuscular
-on post ganglionic side the parasympathetic transmitter was known to be acetylcholine.
acetylcholine act on muscarinic AChR, not nico. this are metabotropic (g-protein couple). for
sympathetic side, the neurotransmitter is norepiniphrine. there are 2 major cases of adrogic
receptors: alpha and beta. norepiniphrine bind to one of receptor Preganglionic Postganglionic ACh Target Cells ACh Muscarinic AChRs Norepi α1, α2, β1, β2, β3 ARs Parasymp. nAChRs (fast EPSP) Symp.
ACh Transmitters & Receptors (Current View)
more info: modern view shows that gangli...
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- Spring '09
- heart rate, target organ