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Organic II - lab 2

Organic II - lab 2 - MCMP 205 Laboratory Exercise 2...

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MCMP 205 Laboratory Exercise 2 1 Exercise 2. Electrophilic Aromatic Substitution: Nitration of Phenol Required Reading: Chapter 16 in the lecture text. Pay special attention to sections 16.4 and 16.5. Objective: This experiment has been designed to understand the mechanism of electrophilic aromatic substitution. In this two week lab exercise, you will carry out nitration of phenol analyze the products using thin-layer chromatography during the first week. During the second week of this lab you will be carrying out column chromatography to separate the various products formed in the reaction. This experiment will also demonstrate how thin-layer chromatography is used to monitor the progress of a column separation. Understanding the experiment Nitration of Phenol Aromatic compounds react with nitric acid, usually in the presence of sulfuric acid as a catalyst, to form nitroaromatic compounds. This reaction, called nitration , introduces a nitro group, —NO