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Biochemical Assessment of Cu Status

Transferring sensitivity same as for serum cu

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Unformatted text preview: ls than males, low in infancy, increases to adult values at four months • Sensitivity – not sensitive for marginal Cu deficiency, homeostatically controlled, reliable for Cu deficiency • Specificity o decreases with: infection, malabsorption syndrome, PEM, Wilson’s disease o increases with: stress, inflammation, pregnancy, oral contraceptive use Some interpretive criteria available • Serum Ceruloplasmin • Carries Cu • A ferroxidase that assists in iron transport by oxidizing intracellular Fe2+ to Fe3+ that can combine with transferring • Sensitivity – same as for serum Cu • Specificity – increases in pregnancy, lactation, oral contraceptive use, MI, infectious disease • Measure following supplementation – not widely used • Limited interpretive criteria Erythrocyte SOD Activity – CuZnSOD • Scavenger for free radicals • Decrease in Cu deficiency • Sensitivity o Believed to be a sensitive index of Cu depletion – decreased activity in depleti...
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