Biochemical Assessment of Iron Status

They are present on all cells but especially

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Unformatted text preview: chronic bleeding: o Ulceration of GI tract o Colonic neoplasia o Use of NSAIDS o Allergy to cow’s milk in infants Menstrual Blood Loss o Decreases with oral contraceptive use o Increases with IUD o Interrupted during lactation Pregnancy o Transfer to fetus o Blood loss with delivery o Placenta and cord o 6 months lactation Biological Functions of Iron Heme • most functional Fe is in the form of heme, needed for: o transport of carbon dioxide and oxygen in blood stream (hemoglobin) o transport of carbon dioxide and oxygen in muscle (as myoglobin) Other forms of Fe • other forms of Fe participate as part of enzymes in: o electron transport o metabolism o cell proliferation Utilization of Fe Erythropoiesis (red blood cell formation) • most absorbed iron is taken up by erythroid precursors in bone marrow by transferrin mediated delivery via transferrin receptors on erythroblasts • Fe uptake to erythroblast and other tissues • Serum transferrin receptors are part of a system controlling iron uptake and storage. They are present on all cells, but especially hemoglobin producing cells. When iron stores are low and erythrobla...
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