{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Biochemical Assessment of Iron Status

Life can significantly impair mental and motor

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: sts require more iron for hemoglobin synthesis more transferrin receptors are found on cell membranes and in plasma. Heme/Hemoglobin Synthesis Heme (in mitochondria) • " " Protoporphyrinogen "" Protoporphyrin III " Heme • Enzyme ferro chelatase catalyzes reaction Protoporphyrin III " Heme - Fe2+ needed for this enzyme to function • Heme is the functional site in hemoglobin, myoglobin and heme containing enzymes Hemoglobin • Heme incorporates globin molecule: Heme " Globin • 2α + 2β globin " hemoglobin • reticulocytes are released into circulation and develop into mature erthyrocytes Clinical Aspects of Iron Nutrition • common practice to define level if iron deficiency severity depending on presence or absence of anemia • more advanced iron deficiency is accompanied by a reduction in packed cell volume or decreased hemoglobin concentrations – iron deficiency anemia (IDA) • evidence of milder iron deficiency, without anemia, may be referred to as iron deficiency (ID) Effects of Iron Deficiency • physical effects include anemia, angular stomatitis, glossitis, koilonychia (spoon nails) • behavio...
View Full Document

{[ snackBarMessage ]}

Ask a homework question - tutors are online