Biochemical Assessment of Iron Status

Microcytic small rbc in iron deficiency as well as

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: (but no anemia) Fe deficiency anemia • Most advanced stage of iron deficiency in which normal red cells are replaced by hypochromic microcytic cells • Depletion of iron stores, decrease in circulating iron • Iron deficiency is the most common cause of anemia Common definitions of iron deficiency anemia: • Anemia with biochemical evidence of concurrent iron deficiency • [Hemoglobin] less than 2 SD below mean of healthy population of the same sex, age, physiological state and altitude • Anemia which can be improved by 10g/L Hb, following 1- 2 months of oral iron supplementation Laboratory Assessment of Fe Status • Technology evolving • No single test or combination of tests is suitable for all purposes • Depends on severity of deficiency, age, and sex of target population, potential for associated disease Hematological Tests Hemoglobin • Measure of functional Fe in body • Most commonly used screening test for anemia in primary are and field surveys (hemocue) • Easy and inexpensive, but need for proper training and standardization • Sensitivity: low, poor, detects only third stage (only appears late in deficiency)...
View Full Document

Ask a homework question - tutors are online