Biochemical Assessment of Iron Status

Result in falsely normal values in an fe deficient

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Unformatted text preview: • Specificity: other causes of anemia: B6, B12, riboflavin, Cu, or folate deficiencies, PEM, chronic disease, parasitic infections, thalassemia, lead poisoning, vitamin A deficiency, haemolytic anemia (malaria), etc. o Also affected by race, pregnancy (#), altitude (#), cigarette smoking o Data usually compared to reference data or hospital/lab data Hematocrit • Red blood cell volume / Total cell volume • Rise and fall parallels Hb • Combined with Hb, most commonly used test for screening for anemia • Equipment – centrifuge • Sensitivity – as per Hb – poor • Specificity – low as per Hb • Reference cut- off values available, not compared to reference values in lab MCV (Mean Corpuscular Volume) • Index derived from Hb, Hct, and RBC count • • • • • Average size of RBC Requires cell counter for best determination Can be calculated from Hb and RBC count Sensitivity – poor – MCV only decreases with severe iron deficiency Specificity – microcytic (small RBC) in iron deficiency as well as chronic disease, thalassemia, lead poisoning vitamin B6 deficiency MCH – Mean Cell Hemoglobin • Hb content o...
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