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Unformatted text preview: t their own genetic makeup
BRCA Mutations (Breast & Ovarian Cancer)
● Substantial risks
● Inheritance – dominant way
Disclosing one’s genetic information can affect another’s
● Ex:) One sister wants to know genetic makeup, the other doesn’t;7 tested sister has BRCA
mutation, we know her parents had it, so the other sister (that doesn’t want to know) has 50%
chance of BRCA mutation too
What if non-
disclosure leads to incorrect tests being ordered?
At first, BRCA mutation was mostly focused, but later other gene mutations were found as well
● Debilitating, progressive neurological disease – lack of control over motor system & *personality
lucky to angry, even suicidal, etc.)
● Median age of onset: 35-
● Autosomal dominant
● Carriers can’t be distinguished from those who don’t, until the onset of disease
● Complicated – do people want to know if they have these genes?
● Prenatal diagnosis
○ Amniocentesis – sample fetal tissue
○ Fetal tissue – test for mutation/specific changes
○ Women use information that the amino reveals to decide whether to keep the baby or not
Tricky case: mother wants to know if child has risk of Huntington, dad doesn’t want to know if he has...
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