Class 14 what we look like what mendel can tell us

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: etic Effects ▪ Monogenic- dominant, codominant, recessive ▪ Oligogenic ▪ ● ● ● ● ● ● ● ● ● Complex Traits- polygenic, age effects, gene environment interaction, gene sex interaction, environment by sex interaction Evolution of Human Lifestyle and Diet o Hunter Gatherers and then Neolithic ▪ Evolutionary Hypothesis: Pandemic of obesity is caused by a profound mismatch between humanity’s present environmental circumstances and those that have molded evolutionary selection. o Thrifty Genotype- 1962 James Neel ▪ Noninsulin dependent diabetes mellitus is the result of a 
thrifty genotype rendered detrimental by cultural change ▪ over- secretion of insulin which increases fat tissue formation and the accumulation of an energy store. ▪ allowing ancestors to build up fat deposits in times of plenty ▪ detrimental – overproduction of insulin leads to insulin resistance, high levels of blood glucose, and diabetes Epigenetics- study of mechanism by which genes bring about their phenotypic effects, study of heritable change in gene function that occur without a change in the sequence of DNA Thrifty Phenotype o Fetus adapts to malnutrition be decreased growth, and altered growth and function of the pancreas (insulin) o Over nutrition later in life makes this developmental adaptation disadvantageous Biliopancreatic diversion bariatric surgery: portion of stomach removed, food you eat bypasses much of small intestine Obesogens o Obesity has risen...
View Full Document

This document was uploaded on 03/11/2014 for the course IB 35AC at University of California, Berkeley.

Ask a homework question - tutors are online