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Unformatted text preview: rican even though mom is white, dad is Kenyan
● “one drop” rule
● DNA ancestry testing: 57% Indo-
European, 39% Native American, 4% East Asian
● Race depends on life experiences rather than biological;7 this is what the Census is
asking – self-
Lecture 27 Bioethics
Guest Lecturer: Bill Campbell (Genetic Counselor)
Genetic Information Ownership
● HeLa genome publication as violation of autonomy
● Respect for autonomy
● Consequences of respecting autonomy
Scientists – figure out which cells are HeLa cells (which are invading human bodies) and which aren’t
● Skloot was outraged – this was violation of different laws, including HIPPA
● “The Genomic and Transcriptomic Landscape of a HeLa cell line” – Journal article (Landry et
● in this process, they put the entire genome online - people are outraged (Skloot, family members,
What can you learn about heritable conditions from reading a genome?
● Mendelian disease vs. Common disease
● Mendelian: follow Mendelian pattern of inheritance
● Common disease: heart disease, cancer, Alzheimer’s, etc.
● Autosomal Recessive Hearing Loss
● Most Mendelian disease - people are born with, but there are also some exceptions
Common diseases (risks)
● Alzheimer’s Disease (AD)
○ Look at particular gene (AOE) – 3 different alleles that contribute to different kinds of
Alzheimer’s ○ Henrietta Lacks: we only know that her kids have a...
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- Spring '08
- The American