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Lecture Notes 7 - Lecture 7 Biosc 0350 Genetics Lecture 7...

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Lecture 7 1/29/2008 1 Biosc 0350 Genetics Lecture 7 - Chromosomal Theory of Inheritance (2) l Review of meiosis and genetic diversity Chromosomes and sex determination Validation of chromosomal theory of inheritance Detecting sex-linked inheritance 1/29/08 Martens. Biosc 0350, University of Pittsburgh 2 Meiosis contributes to genetic diversity Hartwell et al , 3rd ed. Fig. 4.17
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Lecture 7 1/29/2008 2 1/29/08 Martens. Biosc 0350, University of Pittsburgh 3 One chromosome pair determines an individual’s sex. Human chromosomes Hartwell et al , 3rd ed. Fig. 4.4 1900’s Walter Sutton studying grasshoppers Parent cells contained 22 chromosomes plus an X and a Y chromosome chromosome daughter cells cells contained 11 chromosomes and X or Y in equal numbers sperm (X) fertilizes egg --> female (XX) sperm (Y) fertilizes egg --> male (XY) Hartwell et al , 3rd ed. Fig. 4.6 1/29/08 Martens. Biosc 0350, University of Pittsburgh 4 Sex determination in humans Children receive only Children receive only an X chromosome from an X chromosome from mother but X or Y from mother but X or Y from father father Hartwell et al , 3rd ed. Fig. 4.6
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Lecture 7 1/29/2008 3 1/29/08 Martens. Biosc 0350, University of Pittsburgh 5 Anatomy Anatomy of sex of sex chromosomes chromosomes Hartwell et al , 3rd ed. Fig. 4.6 Genes in the differential regions are _____________ in males Genes in differential region of X show X linkage Genes in differential region of Y show Y linkage Genes in homologous region show ______________ inheritance 1/29/08 Martens. Biosc 0350, University of Pittsburgh 6 Variation in how chromosomes determine sex Hartwell et al , 3rd ed.
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