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Lecture Notes 18 - 1 Each chromosome is made up of one DNA...

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Oke, Genetics 0350, Lecture 18, 3/20/2008 Each chromosome is made up of one DNA molecule: Griffiths, 8th Ed., Fig. 3-9 and 3-10 DuPraw, 1960 No ends Kavenoff & Zimm, 1973 Recoil rate 1
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Oke, Genetics 0350, Lecture 18, 3/20/2008 Griffiths, Fig. 4-13 heterochromatin euchromatin Chromatin: all the material that composes a chromosome 1/3 DNA 1/3 histone proteins 1/3 other proteins 2
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Oke, Genetics 0350, Lecture 18, 3/20/2008 Brooker 2nd Ed., Fig. 10.22 Visualization of scaffold after treating to remove histones: 3
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Oke, Genetics 0350, Lecture 18, 3/20/2008 Chromosome structure: nucleosomes Fig. 13.3 4
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Oke, Genetics 0350, Lecture 18, 3/20/2008 Fig. 13.4 Levels of DNA compaction: Radial loop-scaffold model 10,000 fold 7 fold 40-50 fold 5
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Oke, Genetics 0350, Lecture 18, 3/20/2008 Fig. 13.6 G-banding: Metaphase chromosomes Partially digest protein Stain with Giemsa reagent Karyotype: 2000 G-bands in karyotype Bands correspond to 1-10 Mb of DNA 6
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Oke, Genetics 0350, Lecture 18, 3/20/2008 heterochromatin euchromatin Constitutive vs. facultative heterochromatin Chromosomal packaging influences gene activity: 7
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Oke, Genetics 0350, Lecture 18, 3/20/2008
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