Opium Analgesics

Pharmacophore basedonsars ho o n h ho ch3

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Unformatted text preview: lopment of Development of morphine analogues Remember this pharmacophore example? Development of Development of morphine analogues Extension of drug HO O Vary substituents N CH3 H HO HO HO O HO O O N OH HO N CH3 H HO oxymorphine N OH O nalorphine naltrexone Development of Development of morphine analogues Extension of drug HO A O B D E Vary substituents N C Simplification CH3 H HO HO CH3 HO Et N CH3 EtO2C EtOC N CH3 bremazocaine (a benzomorphan) Demerol (a 4­phenylpiperidine) Ph N H3C methadone CH3 Development of Development of morphine analogues Extension of drug HO A O Vary substituents Simplification Rigidification (oripavines) buprenorphine B D E N C H HO CH3 Receptor theory Receptor theory µ receptor κ receptor δ receptor σ receptor N phencyclidine Scientific fact Scientific fact or urban legend?...
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This document was uploaded on 03/13/2014 for the course CHEM 4201 at Clayton.

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