2013-10-09 Cannabis

Mostly localized in the mostly central nervous system

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Unformatted text preview: ptors (CB1 Cannabinoid and CB2): and First discovered in 1988 Receptors are found in the Receptors cerebral cortex, hippocampus, limbic system, and basal ganglia system, - Metabotropic receptors (linked to G-proteins) Mechanism of Action Mechanism Cannabinoid receptors: CB1 receptor: - Mostly localized in the Mostly central nervous system, and mediates the psychoactive properties of THC - Found on various parts of the neuron, including the axon, cell bodies, and dendrites dendrites Mechanism of Action Mechanism Cannabinoid receptors: CB2 receptor: - Mostly localized in the Mostly periphery, and most likely mediates the effects of THC on the immune system - Much less is known about this receptor subtype this Mechanism of Action Mechanism Cannabinoid receptors: CB1 receptor: - iinhibits voltage-gated Ca channels (inihbits nhibits neurotransmitter release) neurotransmitter - opens K+ channels (hyperpolarizes and makes AP less opens likely) likely) - Location on axon terminals inhibits the release of many Location neurotransmitters. neurotransmitters. - Why do we have cannabinoid receptors? Mechanism of Action - Endocannabinoids Mechanism Endocannabinoids: a method Endocannabinoids: the brain has for controlling and reducing neurotransmission. neurotransmission. Endocannabinoids like Endocannabinoids Anandamide and 2-AG are synthesized and released from the postsynaptic cell back to the presynaptic cell. (opposite of normal) (opposite Roles still being researched; Roles involved in pain, memory, appetite, and many diseases. appetite, Cannabinoid Receptors in the Brain Cannabinoid Cannabinoid Receptors in the Brain Cannabinoid Cerebral Cortex (especially the frontal cortex): - dreamlike state of the high - distortion in time, sound, color, taste, ability to distortion concentrate, and mood effects concentrate, Basal Ganglia and Cerebellum: - effects on movement and postural control effects Hippocampus: - disruption of memory and memory storage disruption Hypothalamus: - decreased production of reproductive hormones decreased Cannabinoid Receptors in the Brain Cannabinoid Few...
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This document was uploaded on 03/18/2014 for the course NROSCI 0081 at Pittsburgh.

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