2013-10-09 Cannabis

The reward system are therefore indirect indirect thc

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Unformatted text preview: or no cannabinoid receptors in the dopaminergic neurons Few of the ventral tegmental area (the reward pathway) of - However, marijuana does activate central reward However, pathways, leading to dopamine release in the nucleus accumbens accumbens - Therefore, marijuana’s effect on the reward system are Therefore, indirect indirect THC causes DA release in the NAc THC decreases GABA inhibition of VTA neurons. Therefore, increased firing of DA neuron and increased release into the nucleus accumbens. How might this system affect natural rewards? Endocannabinoids and Appetite Endocannabinoids Mechanism of Action – Cannabidiol Mechanism • While THC is the predominant psychoactive component in While cannabis, the other chemicals can modify its effects. cannabis, • Cannabidiol (CBD) is a CB1/2 antagonist, and prevents THC Cannabidiol from binding. from • CBD is also a serotonin receptor agonist, giving it antidepressant effects. • Marijuana that has higher CBD:THC ratio (Indica as opposed Marijuana to Sativa) produce less anxiety and are more sedating. to • Pure CBD can relieve nausea, convulsions, anxiety, and Pure may be a potent anti-cancer agent by turning off cancer genes or by stimulating the immune system to kill cancerous cells in our bodies. cells Medical Uses Medical • Marijuana (where legal) or Marinol (synthetic THC) • Treatment of nausea and vomiting from drug treatment Treatment in cancer and HIV/AIDS patients in - used when conventional drugs fail used • • • • • • • Glaucoma Pain Cancer Anorexia Nervosa Tourette Syndrome Gastrointestinal disorders PTSD Tolerance Tolerance • Tolerance to cannabinoids does develop, but Tolerance many users do not notice it at first many...
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