2013-10-09 Cannabis

Which pharmacokinetics pharmacokinetics routes of

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Unformatted text preview: lites, some of which THC are also psychoactive are • Major metabolite is 11-hydroxy-delta -9-THC, Major which passes more easily through the BBB. which Pharmacokinetics Pharmacokinetics • Routes of administration: inhalation and oral • Smoking / Vaporization: dose depends on – – – – THC concentration in the marijuana How deeply smoke is inhaled How long smoke is held in lungs User’s experience • Very lipid soluble - rapidly absorbed into the bloodstream and distributed Very to brain. Much of the initial brain levels are gone in 30 minutes. to • Much is diverted to lipid tissues and released over a long period of time. Much • After 1 week, 25-30% of THC and metabolites may remain in body. After Complete elimination of a large dose may take 2-3 weeks. Complete Pharmacokinetics Pharmacokinetics Maximum intoxication occurs after blood levels begin to Maximum Pharmacokinetics Pharmacokinetics • Orally, much less THC reaches the brain • Takes much longer to have psychological effects • Effects last longer • Much broken down in gut or liver • Oral intake often followed by nausea, discomfort and Oral hangover; dose cannot be monitored as accurately as with smoking as Dose-response Dose-response • Isolation of THC has allowed for dose-response Isolation relationship to be determined relationship Smoked 2 mg 7 mg 15 mg Oral 5 mg 17 mg 25 mg Effect mild euphoria changes in time sense Marked changes in body Marked image, perceptual distortions, delusions or hallucinations hallucinations Behavioral and Physiological Effects Behavioral Effects of cannabinoid use vary depending on dose, Effects frequency of use, characteristics of the user, and the setting in which use occurs. the Subjective and behavioral effects of marijuana use Subjective can be separated into four stages: - the “buzz” – brief period of sensory confusion confusion - the “high” – euphoria and exhilaration - being “stoned” – relaxation, introspection - the “come-down” – tiredness, depression Occasionally rapid mood changes and transient Occasionally ps...
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