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Unformatted text preview: lites, some of which
are also psychoactive
• Major metabolite is 11-hydroxy-delta -9-THC,
which passes more easily through the BBB.
• Routes of administration: inhalation and oral
• Smoking / Vaporization: dose depends on
– THC concentration in the marijuana
How deeply smoke is inhaled
How long smoke is held in lungs
User’s experience • Very lipid soluble - rapidly absorbed into the bloodstream and distributed
to brain. Much of the initial brain levels are gone in 30 minutes.
to • Much is diverted to lipid tissues and released over a long period of time.
Much • After 1 week, 25-30% of THC and metabolites may remain in body.
Complete elimination of a large dose may take 2-3 weeks.
Pharmacokinetics Maximum intoxication occurs after blood levels begin to
• Orally, much less THC reaches the brain
• Takes much longer to have psychological effects
• Effects last longer
• Much broken down in gut or liver
• Oral intake often followed by nausea, discomfort and
hangover; dose cannot be monitored as accurately
as with smoking
• Isolation of THC has allowed for dose-response
relationship to be determined
15 mg Oral
25 mg Effect
changes in time sense
Marked changes in body
distortions, delusions or
hallucinations Behavioral and Physiological Effects
Effects of cannabinoid use vary depending on dose,
frequency of use, characteristics of the user, and
the setting in which use occurs.
Subjective and behavioral effects of marijuana use
can be separated into four stages:
- the “buzz” – brief period of sensory
- the “high” – euphoria and exhilaration
- being “stoned” – relaxation, introspection
- the “come-down” – tiredness, depression
Occasionally rapid mood changes and transient
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- Fall '08