CoordinationChemistry L0 bw

CoordinationChemistry L0 bw - Chemistry of the d -Block...

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1 Chemistry of the d -Block Elements History: Louis Nicolas Vauquelin 16. Mai 1763 – 14. Nov. 1829 Leopold Gmelin 2. Aug. 1788 – 13. Apr. 1853 Chemistry of the d -Block Elements History: Pd NH 3 NH 3 H 3 N H 3 N Pd Cl Cl Cl Cl Co III CN CN NC NC NC CN Louis Nicolas Vauquelin 1813 Gmelin 1822
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2 Chemistry of the d -Block Elements History: 1844: Peyrone’s Chloride [PtCl 2 (NH 3 ) 2 ] 1844: Reiset [PtCl 2 (NH 3 ) 2 ] ! (isomers are super-important in chemistry!) -- note! same formula! -- cis- and trans- Platinum Isomers: Serendipity in Chemistry "Testicular cancer went from a disease that normally killed about 80% of the patients, to one which is close to 95% curable. This is probably the most exciting development in the treatment of cancers that we have had in the past 20 years. It is now the treatment of first choice in ovarian, bladder, and osteogenic sarcoma [bone] cancers as well." —Barnett Rosenberg, who led the research group that discovered cisplatin, commenting on the impact of cisplatin in cancer chemotherapy Cisplatin was approved by the FDA for the treatment of genitourinary tumors in 1978. Since then, Michigan State has collected over $160 million in royalties from cisplatin and a related drug, carboplatin, which was approved by the FDA in 1989 for the treatment of ovarian cancers. Pt NH 3 3 O O O O carboplatin Prof. Barnett Rosenberg, MSU (Prof. S.J. Lippard, MIT) Chemistry of the d -Block Elements Newest generation:
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3 Chemistry of the d -Block Elements B. Rosenberg et al. in Nature 1965, 205, 698 Stephen J. Lippard et al. in Nature (1999), 399 , 708 - 712 Basis for recognition of cisplatin-modified DNA by high-mobility-group proteins SUMMARY: The anticancer activity of cis -diamminedichloroplatinum(II) (cisplatin) arises from its ability to damage DNA, with the major adducts formed being intrastrand d(GpG) and d(ApG) Cisplatin acts by cross-linking DNA in several different ways, making it impossible for rapidly dividing cells to duplicate their DNA for mitosis . The damaged DNA sets off DNA repair mechanisms, which activate apoptosis when repair proves impossible. The trans-isomer does not have this pharmacological effect. Barnett Rosenberg, MSU (1926 - ) Chemistry of the d -Block Elements B. Rosenberg et al. in Nature 1965, 205, 698 Stephen J. Lippard et al. in Nature (1999), 399 , 708 - 712 Basis for recognition of cisplatin-modified DNA by high-mobility-group proteins SUMMARY: The anticancer activity of cis -diamminedichloroplatinum(II) (cisplatin) arises from its ability to damage DNA, with the major adducts formed being intrastrand d(GpG) and d(ApG) Cisplatin acts by crosslinking DNA in several different ways, making it impossible for rapidly dividing cells to duplicate their DNA for mitosis . The damaged DNA sets off DNA repair mechanisms, which activate apoptosis when repair proves impossible. The trans isomer does not have this pharmacological effect.
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CoordinationChemistry L0 bw - Chemistry of the d -Block...

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