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INTROANSvF_Bb_Arnot - Introduction to the ANS Physiology...

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Introduction to the ANS Physiology Text Figures : Principles of Human Physiology Germann & Stanfield, 2 nd Ed.
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Lecture Objectives I. Review synaptic transmission & signal transduction II. Review organization of nervous system III. Peripheral Nervous System IV. Autonomic Nervous System A. Parasympathetic B. Sympathetic Division 1. Anatomy 2. Neurotransmission & Neurochemical metabolism 3. Receptors 4. Physiology 5. Regulation V. Case Study
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Synapse Post-synaptic Cell Pre-synaptic Cell I. Review: Neurotransmission & Signal Transduction
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Neurotransmission through a Chemical Synapse Post Synaptic Density (PSD) Reuptake transporter
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Central Nervous System : Brain Spinal Cord II. Organization of the Nervous System Input Afferent Output Efferent Peripheral Nervous System Somatic Autonomic Sensory Autonomic Parasympathetic Sympathetic Parasympathetic Sympathetic
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Smooth muscle Gland cells Cardiac muscles Somatic Sensory Autonomic Skeletal muscle Specialized sensory tissue Viseral Effectors Efferent Pathways Afferent Pathways III. Peripheral Nervous System
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Preganglionic Cell Postganglionic Cell
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IV. ANS Efferent pathways involved in unconscious homeostatic control involves autonomic nervous system (ANS) Dual Innervation Parasympathetic and sympathetic activities tend to oppose each other Enteric Nervous System
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Areas of the Brain involved in Autonomic control Germann and Stanfield Figure 12.12 Maintenance of homeostasis Emotions Cerebral cortex Limbic system
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Germann and Stanfield Figure 12.6 Parasympathetic Nervous System Cranial Nerve 10=? cranial
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Germann and Stanfield Figure 12.2 Sympathetic Nervous System originate in thoracolumbar spinal cord
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Anatomy of Sympathetic Preganglionic and Postganglionic Neurons Germann and Stanfield Figure 12.3 Exception: Collateral ganglia or prevertebral ganglia ( outside chain) Adrenal medulla
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Germann and Stanfield Figure 12.4 Sympathetic Pathway to and from Sympathetic Chain
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To Other Paravertebral Ganglia To Other Paravertebral Ganglia To Prevertebral Ganglia Post Ganglionic to Effector Spinal Column T1 - L2 Sympathetic Nerves
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Sympathetic Innervation of the Adrenal Medulla Germann and Stanfield Figure 12.5 Neurotransmitters of Adrenal Medulla: Catecholamines 80% epinephrine 20% norepinephrine Little dopamine (not significant)
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Preganglionic neurons Parasympathetic postganglionic neurons Sympathetic postganglionic neurons NOTE : Somatic nervous system acetylcholine . IV. A&B. 2. Neurotransmitters of ANS
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Acetylcholine Choline Choline Acetyl Coenzyme A Choline transporter + Acetyltransferase Acetylcholinesterase (AChE) ACh m or n Ach R Fig. 11.3 Kalant et al.
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http://web.indstate.edu/thcme/mwking/aminoacidderivatives.html Fig. 11.5 Kalant et al Catecholamine Synthesis
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Noradrenalin and Adrenalin Adrenoceptor L-tyrosine L-tyrosine L-Dopa Dopamine NE or Epi Tyrosine dehydroxylase Dopa decarboxylase DA NA Dopamine E -hydroxylase D 2 AdrR E 2 AdrR Fig. 11.5 Kalant et al
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