Neuro biology class notes 9

Neuro biology class notes 9 - Slow Coupling and Calcium...

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10/8/13 Slow Coupling and Calcium: Signal Transduction Signal transudciton 1. Intracellular response to an extracellular cue 1.i) Reception: ligand molecule interacts with cell surface receptor 1.ii) Transduction: relay mechanism (1.ii.1) Signal transduced from proeitn to response 1.iii) Response (1.iii.1) Initiated by protein 1.iv) Termination (1.iv.1) End response Mechanisms 1. Channel gated receptor: ions ligands and NTs 1.i) Ex: nAChR- ACh binds to receptor (1.i.1) Opens channel activity is altered 2. Enzyme linked receptor: ligand binds to outside 2.i) Induces conformational change; change shape and changes enzyme function (2.i.1) Can activate of deactivate 3. G protein coupled receptor: ligand binds to receptor 3.i) Protein changes shape (3.i.1) Cascade to change other proteins ***not an enzyme 4. Intracellular Receptor: receptor in cytoplasm 4.i) Bind to melecules that diffuse through membranes (4.i.1) Hydrophobic molecules (steroids) G Protiens 1. Ligands bind to GPCR in membrane 1.i) Activate cellular molecules
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