NEUR 335 Presentation 1 - Ion-channel defects and aberrant...

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Ion-channel defects and aberrant excitability in myotonia and periodic paralysis Stephen C. Cannon 1996
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Remember myotonia? Wiest is Hot Neuromuscular disorder Muscle membrane excitability is enhanced Leads to prolonged muscle contraction after a voluntary nerve impulse
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Periodic paralysis
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Enhanced excitability Reduced excitability Mixed effects Periodic Paralysis Myotoni a Chloride channel Sodium channel Calcium channel Symptoms and their causes
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Neuromuscular Junction Review
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Na+ Channel Disorders Symptoms of both myotonia and paralysis Dependent on percentage of defective Na+ channels -Identified in HyperPP (periodic paralysis), PMC and other myotonias called sodium- channel myotonias (SCMs) -In HyperPP muscle fibers sodium channels failed to inactivate >> persistent sodium current Causes repetitive discharge during
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K+ found to be responsible for after- discharges (discharges after stimulation stops) T-tubules have limited
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  • Spring '11
  • Dr.MikeWeist
  • Na+ channels, periodic paralysis, Muscle membrane excitability, Reduced excitability, Enhanced excitability

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