Lecture+39_Endocrine4_Revised-3

19 10 p 697 chronic stress corsol secreon is adapve

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Unformatted text preview: dney Interna>onal (2009) 76, 811–812. doi:10.1038/ki.2009.282 Adrenal Cortex •  Sex hormones are also produced in the adrenal cortex: –  Testosterone and estradiol are produced in small amounts –  most significant is dehydroepiandosterone (DHEA), a weak androgen •  regulates sex drive and parts of pubertal development in women •  Believed to be less important in men since testosterone is much stronger Cor=sol Hypersecre=on •  Cushing’s syndrome •  Causes: –  pituitary tumor increasing ACTH secre=on –  adrenal tumors secre=ng excess cor=sol –  over- medica=on with glucocor=coid agonists •  Signs and symptoms: –  hyperglycemia and glucosuria (adrenal diabetes) –  abnormal fat distribu=ons “buffalo hump” and “moon face” –  infer=lity –  muscle atrophy & weakness Fig...
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This note was uploaded on 03/21/2014 for the course NPB 101 taught by Professor Fuller,charles/goldberg,jack during the Spring '08 term at UC Davis.

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