Lecture+40_Endocrine5

Insulin promotes glut 4 inseron into cell membrane

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Unformatted text preview: 1 Ca2+ 8 β cell Insulin vesicle 9 Stepped Art Fig. 19-17, p. 712 Gastrointestinal hormones (incretins) Blood amino acids Blood amino acids Major control Food intake Parasympathetic stimulation Islet β cells Sympathetic activation (and epinephrine) Insulin secretion Blood glucose Blood fatty acids Blood amino acids Protein synthesis Fuel storage Fig. 19-18, p. 713 Glucose Transporter •  Glucose is moved into cells by the membrane glucose transporter (GLUT). •  Many varia?ons of GLUT. •  GLUT- 4 is the only type that responds to insulin. •  GLUT- 4 is not present in the plasma membrane in the absence of insulin. •  Insulin promotes GLUT- 4 inser>on into cell membrane. World J Diabetes. Jul 15, 2010; 1(3): 68–75. Glucagon •  Glucagon is secreted during the postabsorp>ve state when blood glucose declines. –  Mobilizes energy- rich molecules...
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