Lecture+40_Endocrine5

On polydipsia excess thirst polyphagia excess hunger

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Unformatted text preview: from their stores. –  Increases blood glucose levels. •  In general opposes the ac?ons of insulin. Diabetes Mellitus •  Diabetes Mellitus is the most common of all endocrine disorders. –  8.3% of the US popula?on as of 2010 (CDC) –  $174 billion cost es?mated in 2007 Overall diabetes trends are dominated by type 2, which composes about 95% of diabetes mellitus cases Consequences of Diabetes Mellitus •  Two major types of Diabetes Mellitus: –  type I diabetes: lack of insulin secre?on. •  Autoimmune cause. –  type II diabetes: reduced sensi?vity to insulin. •  Complicated causes related to diet, obesity, exercise, and stress. •  Later stage type II can involve lack of insulin secre?on as pancreas “burns out” Consequences of Diabetes Mellitus •  Acute symptoms include –  polyuria: frequent urina?on –  polydipsia: excess thirst –  polyphagia: excess hunger & food intake –  metabolic acidosis (ketosis) –  muscle was>ng and weakness •  Chronic complica?ons involve: –  degenera>ve disorders of blood vessels and nervous system –  increased risk of kidney failure –  gangrene...
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