19 19 p 716 endocrinology of stress table 19 2 p702

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Unformatted text preview: in secreAon as pancreas “burns out” Consequences of Diabetes Mellitus •  Acute symptoms include –  polyuria: frequent urina?on –  polydipsia: excess thirst –  polyphagia: excess hunger & food intake –  metabolic acidosis (ketosis) –  muscle was>ng and weakness •  Chronic complica?ons involve: –  degenera>ve disorders of blood vessels and nervous system –  increased risk of kidney failure –  gangrene of extremi?es Insulin deficiency Glucose uptake by cells Hepatic glucose output Triglyceride synthesis (or resistance) Lipolysis Amino acid uptake by cells Blood fatty acids Hyperglycemia Intracellular glucose deficiency Protein deg...
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