Multiple Gene Effects

G huntingtons hereditary cancers anticipation a

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Unformatted text preview: is 50% A possible reason for an affected child with unaffected parents is non- paternity: adoption, other father, etc. Complication to the AD (autosomal dominant) pattern: Adult Onset Conditions An individual who inherits the disease but does not develop the condition until adulthood (e.g. Huntington’s, Hereditary cancers) Anticipation: A heritable disorder that exhibits a progressively earlier age of onset with an increased severity in each generation. Tendency of some traits to become more sever and/or earlier onset after several generations. Result of trinucleotide repeat disorders, which expand after successive generations and enhance the phenotype. E.g. Myotonic dystrophy, Fragile X syndrome, Huntington...
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