Tree Uses; Geology and Fossils

These genes are paralogs what is the phylogeny of

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Unformatted text preview: stic “toe” Comparative data on steroid receptors 6 steroid receptors in vertebrates Estrogen receptor alpha and beta Progesterone receptor Androgen receptor Glucocorticoid receptor Mineralocorticoid receptor Sequence similarity suggests some history of gene duplications. These genes are Paralogs. What is the phylogeny of these paralogs? Which are evolutionary sisters, so to speak? What function was the ancestral protein serving? Steroid Receptor Phylogeny AncSR2 is most like a progesterone receptor. Thus, progesterone signaling evolved next. AncSR1 shows the greatest sequence similarity to extant ERs. Thus, the ancestral sequence was likely an estrogen receptor. All six loci have a single ancestral receptor, where one gene does somesort of steroid reception. Reconstructing what state each nucleotide was in at each node helps us construct...
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